Aztreonam treatment of gram-negative septicemia

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Aztreonam treatment of gram-negative septicemia.

Seventy-five aztreonam treatment courses in 74 patients with gram-negative septicemia resulted in 56 clinical cures (75%), 12 partial clinical cures (16%), and 7 clinical failures (9%). Eradication of the original pathogen from the blood was obtained in all patients but two, who had relapses 1 and 4 days, respectively, after treatment. In nine patients (12%) a superinfection was reported. Signi...

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In vitro antibacterial activity of aztreonam against gram-negative bacilli isolated in 1985.

The antibacterial activity of aztreonam (AZT), a newly developed monobactam, against a total of 637 gram-negative bacilli was investigated using clinical isolates from patients with surgical, respiratory and urological diseases in 1985. Against Pseudomonas aeruginosa, AZT exhibited favorable activity similar to that of cefsulodin. AZT also had high antibacterial activity against Klebsiella pneu...

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The susceptibilities of 159 clinical isolates of glucose nonfermentative gram-negative bacilli were determined for eight new monobactam or beta-lactam antibiotics. Imipemide (N-formimidoyl thienamycin) was effective against the largest number of species, although not against Pseudomonas maltophilia. Cefoperazone and ceftazidime, but not cefsulodin, were active against infrequently isolated Pseu...

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Comparison of the inhibitory and bactericidal activity of aztreonam and amikacin against gram negative aerobic bacilli.

Aztreonam has been compared both in vitro and in clinical trials to aminoglycosides in its activity against aerobic gram-negative bacteria. The inhibitory and killing abilities of aztreonam and amikacin were examined against five gram-negative bacillary strains. Time kill analysis was carried out at serum-achievable concentrations (25 micrograms per ml amikacin, 100 and 200 micrograms per ml az...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1986

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.29.2.359